Nicolas is an Associate Professor in the Department of Microbiology and Immunology at the Université de Montréal – CHUM Research Center. He obtained his PhD in medical virology at Pierre et Marie Curie University in Paris. During his post-doc, he described several cellular reservoirs that contribute to the persistence of HIV in infected individuals receiving antiretroviral therapy. He pursued his research as a principal investigator to characterize these reservoirs which represent the main obstacle to HIV eradication. Dr. Chomont is overseeing studies to unravel the molecular mechanisms involved in HIV latency and to develop novel therapeutic strategies aimed at reducing the size of the HIV reservoir.
Dr. Rémi Fromentin, PharmD, Research associate
Rémi obtained his PhD at Université Laval. The primary focus of his current research is to characterize the immunological mechanisms responsible for HIV persistence in long-term ART-suppressed individuals. Through a large collaboration (Delaney AIDS Research Entreprise), he identified several immune checkpoint molecules involved in the establishment and the maintenance of the HIV reservoir in individuals successfully treated with ART. He is currently testing immune checkpoint blockers as novel therapeutic strategies aimed at reactivating and eliminating latently infected cells. When he is not working in the lab, Rémi loves eating, drinking and visiting musea.
Amélie Pagliuzza, Msc, Research assistant
Amélie joined the lab in 2015. A part of her job is to take care of the lab organization, and assist other lab members on their projects. Besides that, she works on several collaborative projects in which she measures the size of the HIV reservoir in samples from participants in clinical trials. Using assays developed in the lab, Amelie can detect and measure the frequency of the few infected cells that persist in people receiving antiretroviral therapy. Amélie is the queen of PCR and TILDA!
Dr. Marta Massanella, Post-doc
Marta grew up in the beautiful city of Barcelona, Spain. She studied Biological Sciences at Universitat Pompeu Fabra (Barcelona) and completed her PhD in Biomedicine at the AIDS Research Institute (IrsiCaixa, Barcelona). She joined the lab as a post-doctoral fellow in 2015 and she is studying the contribution of CD4 T-cell subsets in the maintenance of the HIV reservoir. She is also involved in several clinical projects to determine the influence of timing of ART initiation on the establishment of the HIV reservoir in adults and babies. When not in the lab, she enjoys traveling all over the world, spending time with her friends and she loves dancing any kind of music. Let’s boogie!
Dr. Julia Ruiz, Post-doc
Julia is from Buenos Aires, Argentina. She joined the lab in June 2017, as a post-doc fellow. Her main research interest lies in understanding the role of CD8 T cells responses in HIV persistence. Also, she is currently studying the susceptibility of different CD4 memory T cell subsets to HIV infection. The main goal of her studies is to improve the knowledge in HIV field that may help to achieve a functional cure for this infection.
Dr. Pierre Gantner, Post-doc
Pierre is from Strasbourg, France. He joined the lab in January 2019, as a post-doc fellow. His research interest is focused on understanding the dynamic of HIV reservoirs in different anatomical and cellular compartments from HIV-infected individuals in different clinical and therapeutic settings. His project is now of unraveling the dynamic of clonally-expanded HIV-infected CD4+ T cells during antiretroviral therapy and its role in HIV persistence and cellular ageing.
Caroline Dufour, MSc, PhD candidate
Proudly born in Baie-Comeau (Québec), Caroline just finished a master in cellular and molecular biology at Université du Québec à Trois-Rivières on HIV restriction factors and CRISPR gene editing. She recently joined the lab this January for her PhD and will be working on characterizing replication-competent HIV reservoirs in treated individuals. Besides lab stuff, she likes books, music, photography and plays.
Isabelle Turcotte, BSc, Msc candidate
Isabelle is from Montreal. She had just finished her bachelor’s degree in microbiology and immunology at Université de Montréal when she joined the lab in 2018. The aim of her Msc project is to identify immunological and cellular factors regulating the HIV reservoir. Her work is specifically oriented around aging process and homeostasis mechanisms. During her free time, she never misses a chance to travel and to seek new adventures!