THE CHOMONT LAB

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HIV rapidly targets a diverse pool of CD4+ T cells to establish productive and latent infections. Gantner P, Buranapraditkun S, Pagliuzza A, Dufour C, Pardons M, Mitchell JL, Kroon E, Sacdalan C, Tulmethakaan N, Pinyakorn S, Robb ML, Phanuphak N, Ananworanich J, Hsu D, Vasan S, Trautmann L, Fromentin R, Chomont N. Immunity. 2023.

 

Phenotypic characterization of single CD4+ T cells harboring genetically intact and inducible HIV genomes. Dufour C, Richard C, Pardons M, Massanella M, Ackaoui A, Murrell B, Routy B, Thomas R, Routy JP, Fromentin R, Chomont N. Nature Communications. 2023

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Association between the development of sub-clinical cardiovascular disease and HIV reservoir markers in people with HIV on suppressive ART. Turcotte I, El-Far M, Sadouni M, Chartrand-Lefebvre C, Filali-Mouhim A, Fromentin R, Chamberland A, Jenabian MA, Baril JG, Trottier B, Thomas R, Tremblay CL, Durand M, Chomont N. Clinical Infectious Diseases. 2022

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Long-term effects of early antiretroviral initiation on HIV reservoir markers: a longitudinal analysis of the MERLIN clinical study.

Massanella M, Bender Ignacio RA, Lama JR, Pagliuzza A, Dasgupta S, Alfaro R, Rios J, Ganoza C, Pinto-Santini D, Gilada T, Duerr A, Chomont N. Lancet Microbes. 2021

 

Single-cell TCR sequencing reveals phenotypically diverse clonally expanded cells harboring inducible HIV proviruses during ART.

Gantner P, Pagliuzza A, Pardons M, Ramgopal M, Routy JP, Fromentin R, Chomont N. Nature communications. 2020.

 

The multifaceted nature of HIV latency.

Dufour C, Gantner P, Fromentin R, Chomont N. J Clin Invest. 2020

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Continuous prophylactic ARV/ART since birth reduces seeding and persistence of the viral reservoir in vertically HIV-infected children.

Massanella M, Puthanakit T, Leyre L, Jupimai T, Sawangsinth P, de Souza M, Suntarattiwong P, Kosalarksa P, Borkird T, Kanjanavanit S, Chokephaibulkit K, Hansudewechakul R, Petdachai W, Mitchell JL, Robb ML, Trautmann L, Ananworanich J, Chomont N.   Clin Infect Dis. 2020.

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Abundant HIV-infected cells in blood and tissues are rapidly cleared upon ART initiation during acute HIV infection

Leyre L, Kroon E, Vandergeeten C, Sacdalan C, Colby DJ, Buranapraditkun S, Schuetz A, Chomchey N, de Souza M, Bakeman W, Fromentin R, Pinyakorn S, Akapirat S, Trichavaroj R, Chottanapund S, Manasnayakorn S, Rerknimitr R, Wattanaboonyoungcharoen P, Kim JH, Tovanabutra S, Schacker TW, O'Connell R, Valcour VG, Phanuphak P, Robb ML, Michael N, Trautmann L, Phanuphak N, Ananworanich J, Chomont N; RV254/SEARCH010, RV304/SEARCH013, SEARCH011 study groups. Science Translational Medicine. 2020.

 

Latency Reversing Agents Induce Differential Responses in Distinct Memory CD4 T Cell Subsets in Individuals on Antiretroviral Therapy

Pardons M, Fromentin R, Pagliuzza A,  Routy JP, Chomont N. Cell Reports. 2019.

 

Infrequent HIV infection of circulating monocytes during antiretroviral therapy.

Massanella M, Bakeman W, Sithinamsuwan P, Fletcher JLK, Chomchey N, Tipsuk S, Chalermchai T, Routy JP, Ananworanich J, Valcour VG, Chomont N; SEARCH 011 Study Group. J Virol. 2019.

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Single-cell characterization and quantification of translation-competent viral reservoirs in treated and untreated HIV infection.

Pardons M, Baxter AE, Massanella M, Pagliuzza A, Fromentin R, Dufour C, Leyre L, Routy JP, Kaufmann DE, Chomont N. PLoS Pathog. 2019.

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PD-1 blockade potentiates HIV latency reversal ex vivo in CD4+ T cells from ART-suppressed individuals.

Fromentin R, DaFonseca S, Costiniuk CT, El-Far M, Procopio FA, Hecht FM, Hoh R, Deeks SG, Hazuda DJ, Lewin SR, Routy JP, Sékaly RP, Chomont N. Nat Commun. 2019.

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Inducible HIV RNA transcription assays to measure HIV persistence: pros and cons of a compromise. 

Plantin J, Massanella M, Chomont N. Retrovirology. 2018.

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Residual inflammation and viral reservoirs: alliance against an HIV cure.

Massanella, M., R. Fromentin, and N. Chomont. Curr Opin HIV AIDS. 2016.

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CD4+ T Cells Expressing PD-1, TIGIT and LAG-3 Contribute to HIV Persistence during ART.

Fromentin, R., W. Bakeman, M. B. Lawani, G. Khoury, W. Hartogensis, S. DaFonseca, M. Killian, L. Epling, R. Hoh, E. Sinclair, F. M. Hecht, P. Bacchetti, S. G. Deeks, S. R. Lewin, R. P. Sekaly, and N. Chomont. PLoS Pathog. 2016.

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A Novel Assay to Measure the Magnitude of the Inducible Viral Reservoir in HIV-infected Individuals.

Procopio, F. A., R. Fromentin, D. A. Kulpa, J. H. Brehm, A. G. Bebin, M. C. Strain, D. D. Richman, U. O'Doherty, S. Palmer, F. M. Hecht, R. Hoh, R. J. Barnard, M. D. Miller, D. J. Hazuda, S. G. Deeks, R. P. Sekaly, and N. Chomont. EBioMedicine. 2015.

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HIV persistence in the setting of antiretroviral therapy: when, where and how does HIV hide?

Kulpa, D. A., and N. Chomont. J Virus Erad. 2015.

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Cross-clade ultrasensitive PCR-based assays to measure HIV persistence in large-cohort studies.

Vandergeeten, C., R. Fromentin, E. Merlini, M. B. Lawani, S. DaFonseca, W. Bakeman, A. McNulty, M. Ramgopal, N. Michael, J. H. Kim, J. Ananworanich, and N. Chomont. J Virol. 2014.

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Reduced markers of HIV persistence and restricted HIV-specific immune responses after early antiretroviral therapy in children.

Ananworanich, J., T. Puthanakit, P. Suntarattiwong, K. Chokephaibulkit, S. J. Kerr, R. Fromentin, W. Bakeman, J. Intasan, A. Mahanontharit, S. Sirivichayakul, N. Chomont, and H.-N. S. Group. AIDS. 2014.

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Interleukin-7 promotes HIV persistence during antiretroviral therapy.

Vandergeeten, C., R. Fromentin, S. DaFonseca, M. B. Lawani, I. Sereti, M. M. Lederman, M. Ramgopal, J. P. Routy, R. P. Sekaly, and N. Chomont. Blood. 2013. 

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The role of cytokines in the establishment, persistence and eradication of the HIV reservoir.

Vandergeeten, C., R. Fromentin, and N. Chomont. Cytokine Growth Factor Rev. 2012.

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Finding a cure for HIV: will it ever be achievable?

Lewin, S. R., V. A. Evans, J. H. Elliott, B. Spire, and N. Chomont. J Int AIDS Soc. 2011.

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Maintenance of CD4+ T-cell memory and HIV persistence: keeping memory, keeping HIV.

N. Chomont, S. DaFonseca, C. Vandergeeten, P. Ancuta, and R. P. Sekaly. Curr Opin HIV AIDS. 2011.

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HIV persistence and the prospect of long-term drug-free remissions for HIV-infected individuals.

Trono, D., C. Van Lint, C. Rouzioux, E. Verdin, F. Barre-Sinoussi, T. W. Chun, and N. Chomont. Science. 2010.

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HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation.

N. Chomont, M. El-Far, P. Ancuta, L. Trautmann, F. A. Procopio, B. Yassine-Diab, G. Boucher, M. R. Boulassel, G. Ghattas, J. M. Brenchley, T. W. Schacker, B. J. Hill, D. C. Douek, J. P. Routy, E. K. Haddad, and R. P. Sekaly. Nat Med. 2009.

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